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USC-OGP 2-DE database
Two-dimensional polyacrylamide gel electrophoresis database
USC-OGP 2-DE database
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Searching in 'USC-OGP 2-DE database' for entry
matching:
PDC6I_HUMAN
USC-OGP 2-DE database
:
PDC6I_HUMAN
PDC6I_HUMAN
General information about the entry
View entry in simple text format
Entry name
PDC6I_HUMAN
Primary accession number
Q8WUM4
integrated into USC-OGP 2-DE database on
January 17, 2017 (release 1)
2D Annotations were last modified on
January 17, 2017 (version 1)
General Annotations were last modified on
April 5, 2017 (version 2)
Name and origin of the protein
Description
RecName: Full=Programmed cell death 6-interacting protein; Short=PDCD6-interacting protein; AltName: Full=ALG-2-interacting protein 1; AltName: Full=ALG-2-interacting protein X; AltName: Full=Hp95;.
Gene name
Name=PDCD6IP
Synonyms=AIP1, ALIX, KIAA1375
Annotated species
Homo sapiens (Human) [TaxID:
9606
]
Taxonomy
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]
2D GEL CHARACTERIZATION
Author 1., Author 2.
Submitted (Mar-2011) to Current
2D PAGE maps for identified proteins
How to interpret a protein
UVEAL_MELANOMA_3-10
{UVEAL MELANOMA 3-10}
Homo sapiens (Human)
map experimental info
UVEAL_MELANOMA_3-10
MAP LOCATIONS:
SPOT OGP-1107
:
pI=6.36; Mw=111581
Cross-references
UniProtKB/Swiss-Prot
Q8WUM4; PDC6I_HUMAN.
2D PAGE maps for identified proteins
How to interpret a protein map
You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
Warning 1
: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
Warning 2
: the 2D PAGE map is built on demand. This may take some few seconds to be computed.
External data extracted from
UniProtKB/Swiss-Prot
Extracted from
UniProtKB/Swiss-Prot
, release:
0.0
Entry name
PDC6I_HUMAN
Primary accession number
Q8WUM4
Secondary accession number(s)
C5MQH7 E9PFU1 Q6NUS1 Q9BX86 Q9NUN0 Q9P2H2 Q9UKL5
Sequence was last modified on
March 1, 2002 (version 1)
Annotations were last modified on
March 15, 2017 (version 160)
Name and origin of the protein
Description
RecName: Full=Programmed cell death 6-interacting protein; Short=PDCD6-interacting protein; AltName: Full=ALG-2-interacting protein 1; AltName: Full=ALG-2-interacting protein X; AltName: Full=Hp95;
Gene name
Name=PDCD6IP
Synonyms=AIP1, ALIX, KIAA1375
Encoded on
Name=PDCD6IP; Synonyms=AIP1, ALIX, KIAA1375
Keywords
3D-structure
;
Acetylation
;
Alternative splicing
;
Apoptosis
;
Cell cycle
;
Cell division
;
Cell junction
;
Complete proteome
;
Cytoplasm
;
Cytoskeleton
;
Direct protein sequencing
;
Host-virus interaction
;
Methylation
;
Phosphoprotein
;
Polymorphism
;
Protein transport
;
Reference proteome
;
Secreted
;
Tight junction
;
Transport
.
Copyright
Copyrighted by the UniProt Consortium, see
http://www.uniprot.org/help/license
. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBL
AF349951; AAK20398.1
; -; mRNA
EMBL
GQ131806; ACS12984.1
; -; mRNA
EMBL
AF151793; AAF08220.1
; -; mRNA
EMBL
BT007367; AAP36031.1
; -; mRNA
EMBL
AC112220; -
; NOT_ANNOTATED_CDS; Genomic_DNA
EMBL
AC123901; -
; NOT_ANNOTATED_CDS; Genomic_DNA
EMBL
BC020066; AAH20066.1
; -; mRNA
EMBL
BC068454; AAH68454.1
; -; mRNA
EMBL
AK002122; BAA92092.1
; ALT_INIT; mRNA
EMBL
AB037796; BAA92613.1
; -; mRNA
CCDS
CCDS2660.1; -. [Q8WUM4-1]
; .
CCDS
CCDS54561.1; -. [Q8WUM4-2]
; .
RefSeq
NP_001155901.1; NM_001162429.2. [Q8WUM4-2]
; .
RefSeq
NP_001243121.1; NM_001256192.1. [Q8WUM4-3]
; .
RefSeq
NP_037506.2; NM_013374.5. [Q8WUM4-1]
; .
UniGene
Hs.475896; -
; .
PDB
2OEV; X-ray
; 3.30 A; A=1-698
PDB
2OEW; X-ray
; 2.55 A; A=1-359
PDB
2OEX; X-ray
; 2.58 A; A/B=360-702
PDB
2OJQ; X-ray
; 2.87 A; A=360-702
PDB
2R02; X-ray
; 2.60 A; A=2-698
PDB
2R03; X-ray
; 2.59 A; A=2-698
PDB
2R05; X-ray
; 2.55 A; A=2-698
PDB
2XS1; X-ray
; 2.30 A; A=1-698
PDB
2XS8; X-ray
; 2.50 A; A=1-698
PDB
2ZNE; X-ray
; 2.20 A; C/D=799-812
PDB
3C3O; X-ray
; 2.15 A; A=1-359
PDB
3C3Q; X-ray
; 2.10 A; A=1-359
PDB
3C3R; X-ray
; 2.02 A; A=1-359
PDB
3E1R; X-ray
; 2.00 A; C=797-809
PDB
3WUV; X-ray
; 2.79 A; C/F/I/L/O/R=796-810
PDB
4JJY; X-ray
; 6.50 A; A/B=355-708
PDBsum
2OEV; -
; .
PDBsum
2OEW; -
; .
PDBsum
2OEX; -
; .
PDBsum
2OJQ; -
; .
PDBsum
2R02; -
; .
PDBsum
2R03; -
; .
PDBsum
2R05; -
; .
PDBsum
2XS1; -
; .
PDBsum
2XS8; -
; .
PDBsum
2ZNE; -
; .
PDBsum
3C3O; -
; .
PDBsum
3C3Q; -
; .
PDBsum
3C3R; -
; .
PDBsum
3E1R; -
; .
PDBsum
3WUV; -
; .
PDBsum
4JJY; -
; .
ProteinModelPortal
Q8WUM4; -
; .
SMR
Q8WUM4; -
; .
BioGrid
115332; 111
; .
DIP
DIP-29327N; -
; .
IntAct
Q8WUM4; 55
; .
MINT
MINT-4999333; -
; .
STRING
9606.ENSP00000411825; -
; .
iPTMnet
Q8WUM4; -
; .
PhosphoSitePlus
Q8WUM4; -
; .
SwissPalm
Q8WUM4; -
; .
BioMuta
PDCD6IP; -
; .
DMDM
31076831; -
; .
UCD-2DPAGE
Q8WUM4; -
; .
EPD
Q8WUM4; -
; .
MaxQB
Q8WUM4; -
; .
PaxDb
Q8WUM4; -
; .
PeptideAtlas
Q8WUM4; -
; .
PRIDE
Q8WUM4; -
; .
DNASU
10015; -
; .
Ensembl
ENST00000307296; ENSP00000307387
; ENSG00000170248. [Q8WUM4-1]; .
Ensembl
ENST00000457054; ENSP00000411825
; ENSG00000170248. [Q8WUM4-2]; .
GeneID
10015; -
; .
KEGG
hsa:10015; -
; .
UCSC
uc003cfx.5; human. [Q8WUM4-1]
; .
CTD
10015; -
; .
DisGeNET
10015; -
; .
GeneCards
PDCD6IP; -
; .
H-InvDB
HIX0163463; -
; .
HGNC
HGNC:8766; PDCD6IP
; .
HPA
CAB016212; -
; .
HPA
HPA011905; -
; .
MIM
608074; gene
; .
neXtProt
NX_Q8WUM4; -
; .
OpenTargets
ENSG00000170248; -
; .
PharmGKB
PA33116; -
; .
eggNOG
KOG2220; Eukaryota
; .
eggNOG
ENOG410XQX6; LUCA
; .
GeneTree
ENSGT00780000121909; -
; .
HOGENOM
HOG000006938; -
; .
HOVERGEN
HBG053533; -
; .
InParanoid
Q8WUM4; -
; .
KO
K12200; -
; .
OMA
QVKECYQ; -
; .
OrthoDB
EOG091G04NC; -
; .
PhylomeDB
Q8WUM4; -
; .
TreeFam
TF323502; -
; .
Reactome
R-HSA-162588; Budding and maturation of HIV virion
; .
Reactome
R-HSA-5210891; Uptake and function of anthrax toxins
; .
ChiTaRS
PDCD6IP; human
; .
EvolutionaryTrace
Q8WUM4; -
; .
GeneWiki
PDCD6IP; -
; .
GenomeRNAi
10015; -
; .
PRO
PR:Q8WUM4; -
; .
Proteomes
UP000005640; Chromosome 3
; .
Bgee
ENSG00000170248; -
; .
CleanEx
HS_PDCD6IP; -
; .
ExpressionAtlas
Q8WUM4; baseline and differential
; .
Genevisible
Q8WUM4; HS
; .
GO
GO:0042641; C:actomyosin
; ISS:UniProtKB; .
GO
GO:0005829; C:cytosol
; IDA:HPA; .
GO
GO:0070971; C:endoplasmic reticulum exit site
; IMP:UniProtKB; .
GO
GO:0070062; C:extracellular exosome
; IDA:UniProtKB; .
GO
GO:1903561; C:extracellular vesicle
; IDA:UniProtKB; .
GO
GO:0005925; C:focal adhesion
; IDA:UniProtKB; .
GO
GO:0001772; C:immunological synapse
; IDA:BHF-UCL; .
GO
GO:0042470; C:melanosome
; IEA:UniProtKB-SubCell; .
GO
GO:0016020; C:membrane
; IDA:UniProtKB; .
GO
GO:0005815; C:microtubule organizing center
; IEA:UniProtKB-SubCell; .
GO
GO:0043209; C:myelin sheath
; IEA:Ensembl; .
GO
GO:0048306; F:calcium-dependent protein binding
; IPI:UniProtKB; .
GO
GO:0042803; F:protein homodimerization activity
; IPI:UniProtKB; .
GO
GO:0031871; F:proteinase activated receptor binding
; IPI:UniProtKB; .
GO
GO:0000915; P:actomyosin contractile ring assembly
; ISS:UniProtKB; .
GO
GO:0006915; P:apoptotic process
; IEA:UniProtKB-KW; .
GO
GO:0070830; P:bicellular tight junction assembly
; ISS:UniProtKB; .
GO
GO:0000920; P:cell separation after cytokinesis
; IMP:UniProtKB; .
GO
GO:0045199; P:maintenance of epithelial cell apical/basal polarity
; ISS:UniProtKB; .
GO
GO:0036258; P:multivesicular body assembly
; NAS:ParkinsonsUK-UCL; .
GO
GO:1903543; P:positive regulation of exosomal secretion
; IMP:UniProtKB; .
GO
GO:1903553; P:positive regulation of extracellular exosome assembly
; IMP:UniProtKB; .
GO
GO:0015031; P:protein transport
; IEA:UniProtKB-KW; .
GO
GO:0010824; P:regulation of centrosome duplication
; IMP:UniProtKB; .
GO
GO:1903551; P:regulation of extracellular exosome assembly
; IMP:UniProtKB; .
GO
GO:0090559; P:regulation of membrane permeability
; ISS:UniProtKB; .
GO
GO:0090611; P:ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway
; IMP:UniProtKB; .
GO
GO:0039702; P:viral budding via host ESCRT complex
; IGI:UniProtKB; .
GO
GO:0019058; P:viral life cycle
; TAS:Reactome; .
Gene3D
1.25.40.280; -
; 1; .
InterPro
IPR025304; ALIX_V_dom
; .
InterPro
IPR004328; BRO1_dom
; .
Pfam
PF13949; ALIX_LYPXL_bnd
; 1; .
Pfam
PF03097; BRO1
; 1; .
SMART
SM01041; BRO1
; 1; .
PROSITE
PS51180; BRO1
; 1; .
Gateways to other related servers
The World-2DPAGE Constellation
- Entry point to the world-wide 2-DPAGE resources.
World-2DPAGE Repository
- A public repository for gel-based proteomics data linked to protein identification published in the literature.
World-2DPAGE Portal
- A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
SWISS-2DPAGE
- The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
ExPASy
- The resources web server of the
Swiss Institute of Bioinformatics
Database constructed and maintained by
Angel Garcia
, using the
Make2D-DB II
package (
ver. 3.10.2
) from the
World-2DPAGE Constellation
of the
ExPASy web server
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